One of the books that I have put out as an e-book was firmly turned down by my editor - but I'd finished it anyway, and I liked it even if she didn't, so I put it out to see what would happen. It has sold a few copies already - and done better than some of the previously published titles. It's taken me a while to absorb the implications, but basically, with e-publishing, you cannot fail. There is no gatekeeper to say 'my readers wouldn't like this book'. The readers themselves get to decide.
So what will I write? Well, you know what? I always liked Regency romances. They are hard to sell, but they suit my style - lots of fun and frolics and not too much navel gazing. We are going to Greece for 2 weeks, so I just might treat myself and write a Regency.
But it's a liberating thought, isn't it? You can't fail.